Publication Suzuki Lab
[1] D.M. Rini, Y. Nakamichi, T. Morita, H. Inoue, Y. Mizukami, Y. Yamamoto, T. Suzuki, Xylobiose treatment strengthens intestinal barrier function by regulating claudin 2 and heat shock protein 27 expression in human Caco-2 cells, J Sci Food Agric 104(4) (2024) 2518-2525.
[2] K. Isayama, D.M. Rini, Y. Yamamoto, T. Suzuki, Propionate regulates tight junction barrier by increasing endothelial-cell selective adhesion molecule in human intestinal Caco-2 cells, Exp Cell Res 425(2) (2023) 113528.
[3] W. Xu, Y. Ishii, D.M. Rini, Y. Yamamoto, T. Suzuki, Microbial metabolite n-butyrate upregulates intestinal claudin-23 expression through SP1 and AMPK pathways in mouse colon and human intestinal Caco-2 cells, Life Sci 329 (2023) 121952.
[4] D.M. Rini, Y. Yamamoto, T. Suzuki, Partially hydrolyzed guar gum upregulates heat shock protein 27 in intestinal Caco-2 cells and mouse intestine via mTOR and ERK signaling, J Sci Food Agric 103(10) (2023) 5165-5170.
[5] P.A. Adesina, I. Saeki, Y. Yamamoto, T. Suzuki, N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells, Arch Biochem Biophys 736 (2023) 109525.
[6] S. Nagamatsu, Y. Nishito, H. Yuasa, N. Yamamoto, T. Komori, T. Suzuki, H. Yasui, T. Kambe, Sophisticated expression responses of ZNT1 and MT in response to changes in the expression of ZIPs, Sci Rep 12(1) (2022) 7334.
[7] N.T.T. Tinh, G.C. Sitolo, Y. Yamamoto, T. Suzuki, Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model, Foods 10(2) (2021).
[8] K. Yokoo, Y. Yamamoto, T. Suzuki, Ammonia impairs tight junction barriers by inducing mitochondrial dysfunction in Caco-2 cells, Faseb j 35(11) (2021) e21854.
[9] Y. Mayangsari, N. Sugimachi, W. Xu, C. Mano, Y. Tanaka, O. Ueda, T. Sakuta, Y. Suzuki, Y. Yamamoto, T. Suzuki, 3,5,7,3',4'-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells, J Agric Food Chem 69(35) (2021) 10174-10183.
[10] W. Xu, K. Watanabe, Y. Mizukami, Y. Yamamoto, T. Suzuki, Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest, Arch Biochem Biophys 712 (2021) 109044.
[11] M. Guo, W. Xu, Y. Yamamoto, T. Suzuki, Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells, Arch Biochem Biophys 707 (2021) 108938.
[12] P.A. Adesina, K. Isayama, G.C. Sitolo, Y. Yamamoto, T. Suzuki, Propionate and Dietary Fermentable Fibers Upregulate Intestinal Heat Shock protein70 in Intestinal Caco-2 Cells and Mouse Colon, J Agric Food Chem 69(30) (2021) 8460-8470.
[13] S. Yunika Mayangsari and Mayu Okudaira and Chinatsu Mano and Yuki Tanaka and Osamu Ueda and Tomohiro Sakuta and Yoshiharu Suzuki and Yoshinari Yamamoto and Takuya, 5,7-Dimethoxyflavone enhances barrier function by increasing occludin and reducing claudin-2 in human intestinal Caco-2 cells, Journal of Functional Foods 85 (2021) 104641.
[14] C. Ogawa, R. Inoue, Y. Yonejima, K. Hisa, Y. Yamamoto, T. Suzuki, Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice, J Appl Microbiol 131(6) (2021) 3043-3055.
[15] T. Suzuki, Regulation of the intestinal barrier by nutrients: The role of tight junctions, Anim Sci J 91(1) (2020) e13357.
[16] G.C. Sitolo, A. Mitarai, P.A. Adesina, Y. Yamamoto, T. Suzuki, Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production, Biosci Biotechnol Biochem 84(11) (2020) 2337-2346.
[17] Y. Sakai, H. Arie, Y. Ni, F. Zhuge, L. Xu, G. Chen, N. Nagata, T. Suzuki, S. Kaneko, T. Ota, M. Nagashimada, Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability, J Endocrinol 247(2) (2020) 169-181.
[18] Y. Chaen, Y. Yamamoto, T. Suzuki, Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-alpha production and induction of M2-type macrophages in colitic mice, Nutr Res 64 (2019) 82-92.
[19] Y. Shimizu, T. Suzuki, Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model, Nutr Res 69 (2019) 30-41.
[20] N. Watanabe, T. Suzuki, Y. Yamazaki, K. Sugiyama, S. Koike, M. Nishimukai, Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice, Biosci Biotechnol Biochem 83(4) (2019) 717-727.
[21] Y. Kurose, J. Minami, A. Sen, N. Iwabuchi, F. Abe, J. Xiao, T. Suzuki, Bioactive factors secreted by Bifidobacterium breve B-3 enhance barrier function in human intestinal Caco-2 cells, Benef Microbes 10(1) (2019) 89-100.
[22] T. Hung, J. Wanatanbe, Y. Yonejima, K. Hisa, Y. Yamamoto, T. Suzuki, Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier, Journal of Functional Foods 52 (2019) 276 - 283.
[23] K. Kobayashi, Y. Yatsukawa, M. Tanaka, S. Tanabe, T. Suzuki, Establishment of a method for determining the origin of glutamic acid in processed food based on carbon and nitrogen stable isotope ratios, Heliyon 5(1) (2019) e01169.
[24] M. Abdel-Hamid, E. Romeih, R. Gamba, E. Nagai, T. Suzuki, T. Koyanagi, T. Enomoto, The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage, International Dairy Journal 91 (2019) 1 - 8.
[25] T.V. Hung, T. Suzuki, Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier, J Nutr 148(4) (2018) 552-561.
[26] A. Kawabata, T. Van Hung, Y. Nagata, N. Fukuda, T. Suzuki, Citrus kawachiensis Peel Powder Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, J Agric Food Chem 66(42) (2018) 10991-10999.
[27] K. Kobayashi, M. Tanaka, S. Tanabe, Y. Yatsukawa, T. Suzuki, Distinguishing glutamic acid in foodstuffs and monosodium glutamate used as seasoning by stable carbon and nitrogen isotope ratios, Heliyon 4(9) (2018) e00800.
[28] Y. Mayangsari, T. Suzuki, Resveratrol enhances intestinal barrier function by ameliorating barrier disruption in Caco-2 cell monolayers, Journal of Functional Foods 51 (2018) 39 - 46.
[29] B. Manda, H. Mir, R. Gangwar, A.S. Meena, S. Amin, P.K. Shukla, K. Dalal, T. Suzuki, R. Rao, Phosphorylation hotspot in the C-terminal domain of occludin regulates the dynamics of epithelial junctional complexes, J Cell Sci 131(7) (2018).
[30] Y. Mayangsari, T. Suzuki, Resveratrol Ameliorates Intestinal Barrier Defects and Inflammation in Colitic Mice and Intestinal Cells, J Agric Food Chem 66(48) (2018) 12666-12674.
[31] T.V. Hung, T. Suzuki, Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons, J Agric Food Chem 66(1) (2018) 108-117.
[32] G. Yang, S. Bibi, M. Du, T. Suzuki, M.J. Zhu, Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective, Crit Rev Food Sci Nutr 57(18) (2017) 3830-3839.
[33] M. Ogata, T. Van Hung, H. Tari, T. Arakawa, T. Suzuki, Dietary psyllium fiber increases intestinal heat shock protein 25 expression in mice, Nutr Res 39 (2017) 25-33.
[34] M. Ogata, T. Ogita, H. Tari, T. Arakawa, T. Suzuki, Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice, Br J Nutr 118(9) (2017) 661-672.
[35] T. Van Hung, T. Suzuki, Guar gum fiber increases suppressor of cytokine signaling-1 expression via toll-like receptor 2 and dectin-1 pathways, regulating inflammatory response in small intestinal epithelial cells, Mol Nutr Food Res 61(10) (2017).
[36] M. Oyama, T.V. Hung, K. Yoda, F. He, T. Suzuki, A novel whey tetrapeptide IPAV reduces interleukin-8 production induced by TNF-a in human intestinal Caco-2 cells, Journal of Functional Foods 35 (2017) 376-383.
[37] H. Kaikiri, J. Miyamoto, T. Kawakami, S.B. Park, N. Kitamura, S. Kishino, Y. Yonejima, K. Hisa, J. Watanabe, T. Ogita, J. Ogawa, S. Tanabe, T. Suzuki, Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice, Int J Food Sci Nutr 68(8) (2017) 941-951.
[38] Y. Miyoshi, S. Tanabe, T. Suzuki, Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression, Am J Physiol Gastrointest Liver Physiol 311(1) (2016) G105-16.
[39] Y. Murakami, S. Tanabe, T. Suzuki, High-fat Diet-induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice, J Food Sci 81(1) (2016) H216-22.
[40] T.V. Hung, T. Suzuki, Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, J Nutr 146(10) (2016) 1970-1979.
[41] Y. Kikuchi, H. Yoshida, T. Ogita, K. Okita, S. Fukudome, T. Suzuki, S. Tanabe, In vivo dose response and in vitro mechanistic analysis of enhanced immunoglobulin A production by Lactobacillus plantarum AYA, Biosci Microbiota Food Health 34(3) (2015) 53-8.
[42] J. Miyamoto, T. Mizukure, S.B. Park, S. Kishino, I. Kimura, K. Hirano, P. Bergamo, M. Rossi, T. Suzuki, M. Arita, J. Ogawa, S. Tanabe, A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway, J Biol Chem 290(5) (2015) 2902-18.
[43] Y. Murakami, T. Ojima-Kato, W. Saburi, H. Mori, H. Matsui, S. Tanabe, T. Suzuki, Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets, Br J Nutr 114(11) (2015) 1774-83.
[44] T. Ogita, P. Bergamo, F. Maurano, R. D'Arienzo, G. Mazzarella, G. Bozzella, D. Luongo, T. Sashihara, T. Suzuki, S. Tanabe, M. Rossi, Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology, Immunobiology 220(6) (2015) 701-10.
[45] S. Noda, S. Tanabe, T. Suzuki, Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells, Journal of Functional Foods 10(0) (2014) 112-116.
[46] S. Tanabe, T. Suzuki, Y. Wasano, F. Nakajima, H. Kawasaki, T. Tsuda, N. Nagamine, T. Tsurumachi, K. Sugaya, H. Akita, M. Takagi, K. Takagi, Y. Inoue, Y. Asai, H. Morita, Anti-inflammatory and Intestinal Barrier-protective Activities of Commensal Lactobacilli and Bifidobacteria in Thoroughbreds: Role of Probiotics in Diarrhea Prevention in Neonatal Thoroughbreds, J Equine Sci 25(2) (2014) 37-43.
[47] P. Phuwamongkolwiwat, T. Suzuki, T. Hira, H. Hara, Fructooligosaccharide augments benefits of quercetin-3-O-β-glucoside on insulin sensitivity and plasma total cholesterol with promotion of flavonoid absorption in sucrose-fed rats, Eur J Nutr 53(2) (2014) 457-68.
[48] T. Azuma, M. Shigeshiro, M. Kodama, S. Tanabe, T. Suzuki, Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice, J Nutr 143(6) (2013) 827-34.
[49] E. Miyauchi, T. Ogita, J. Miyamoto, S. Kawamoto, H. Morita, H. Ohno, T. Suzuki, S. Tanabe, Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules, PLoS One 8(11) (2013) e79735.
[50] Y. Nagashio, Y. Matsuura, J. Miyamoto, T. Kometani, T. Suzuki, S. Tanabe, Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity, Journal of Functional Foods 5(4) (2013) 1633-1641.
[51] S. Noda, S. Tanabe, T. Suzuki, Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells, Mol Nutr Food Res 57(11) (2013) 2019-28.
[52] M. Shigeshiro, S. Tanabe, T. Suzuki, Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis, Journal of Functional Foods 5 (2013) 949-955.
[53] T. Suzuki, Regulation of intestinal epithelial permeability by tight junctions, Cell Mol Life Sci 70(4) (2013) 631-59.
[54] E. Miyauchi, M. Morita, M. Rossi, H. Morita, T. Suzuki, S. Tanabe, Effect of D-alanine in teichoic acid from the Streptococcus thermophilus cell wall on the barrier-protection of intestinal epithelial cells, Biosci Biotechnol Biochem 76(2) (2012) 283-8.
[55] S. Noda, S. Tanabe, T. Suzuki, Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells, J Agric Food Chem 60(18) (2012) 4628-33.
[56] M. Shigeshiro, S. Tanabe, T. Suzuki, Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms, Brain Behav Immun 26(7) (2012) 1061-5.
[57] S. Ishizuka, M. Shiwaku, M. Hagio, T. Suzuki, T. Hira, H. Hara, Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to gamma-rays, Biomed Res 33(3) (2012) 159-65.
[58] S. Jain, T. Suzuki, A. Seth, G. Samak, R. Rao, Protein kinase Czeta phosphorylates occludin and promotes assembly of epithelial tight junctions, Biochem J 437(2) (2011) 289-99.
[59] S. Aggarwal, T. Suzuki, W.L. Taylor, A. Bhargava, R.K. Rao, Contrasting effects of ERK on tight junction integrity in differentiated and under-differentiated Caco-2 cell monolayers, Biochem J 433(1) (2011) 51-63.
[60] T. Ogita, M. Nakashima, H. Morita, Y. Saito, T. Suzuki, S. Tanabe, Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells, J Biomed Biotechnol 2011 (2011) 378417.
[61] T. Ogita, Y. Tanii, H. Morita, T. Suzuki, S. Tanabe, Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-gamma, Int J Mol Med 28(5) (2011) 817-22.
[62] T. Suzuki, S. Tanabe, H. Hara, Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells, J Nutr 141(1) (2011) 87-94.
[63] T. Suzuki, N. Yoshinaga, S. Tanabe, Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium, J Biol Chem 286(36) (2011) 31263-71.
[64] S. Ishizuka, K. Saito, T. Suzuki, J. Lee, H. Hara, A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells, Food Chemistry 125 (2011) 1219-1225.
[65] T. Suzuki, H. Hara, Role of flavonoids in intestinal tight junction regulation, J Nutr Biochem 22(5) (2011) 401-8.
[66] G. Samak, T. Suzuki, A. Bhargava, R.K. Rao, c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium, Am J Physiol Gastrointest Liver Physiol 299(3) (2010) G572-84.
[67] T. Suzuki, T. Nishioka, S. Ishizuka, H. Hara, A novel mechanism underlying phytate-mediated biological action-phytate hydrolysates induce intracellular calcium signaling by a Galphaq protein-coupled receptor and phospholipase C-dependent mechanism in colorectal cancer cells, Mol Nutr Food Res 54(7) (2010) 947-55.
[68] T. Suzuki, M. Nishimukai, A. Shinoki, H. Taguchi, S. Fukiya, A. Yokota, W. Saburi, T. Yamamoto, H. Hara, H. Matsui, Ingestion of epilactose, a non-digestible disaccharide, improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal calcium and iron absorption, J Agric Food Chem 58(19) (2010) 10787-92.
[69] T. Suzuki, M. Nishimukai, M. Takechi, H. Taguchi, S. Hamada, A. Yokota, S. Ito, H. Hara, H. Matsui, The nondigestible disaccharide epilactose increases paracellular Ca absorption via rho-associated kinase- and myosin light chain kinase-dependent mechanisms in rat small intestines, J Agric Food Chem 58(3) (2010) 1927-32.
[70] T. Suzuki, H. Hara, Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats, Nutr Metab (Lond) 7 (2010) 19.
[71] T. Suzuki, H. Hara, Phytate hydrolysate induces circumferential F-actin ring formation at cell-cell contacts by a Rho-associated kinase-dependent mechanism in colorectal cancer HT-29 cells, Mol Nutr Food Res (2010).
[72] B.C. Elias, T. Suzuki, A. Seth, F. Giorgianni, G. Kale, L. Shen, J.R. Turner, A. Naren, D.M. Desiderio, R. Rao, Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions, J Biol Chem 284(3) (2009) 1559-69.
[73] T. Suzuki, B.C. Elias, A. Seth, L. Shen, J.R. Turner, F. Giorgianni, D. Desiderio, R. Guntaka, R. Rao, PKC eta regulates occludin phosphorylation and epithelial tight junction integrity, Proc Natl Acad Sci U S A 106(1) (2009) 61-6.
[74] T. Suzuki, H. Hara, Quercetin enhances intestinal barrier function through the assembly of zonula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells, J Nutr 139(5) (2009) 965-74.
[75] T. Suzuki, A. Seth, R. Rao, Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers, J Biol Chem 283(6) (2008) 3574-83.
[76] T. Suzuki, S. Yoshida, H. Hara, Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability, Br J Nutr 100(2) (2008) 297-305.
[77] H. Hiroshi, T. Suzuki, Recent knowledge in mechanisms of improved calcium absorption by a nondigestible saccharides, difructose anhydride, Research Signpost (2007) 311-322.
[78] T. Suzuki, H. Hara, Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells, Life Sci 79(4) (2006) 401-10.
[79] T. Suzuki, H. Hara, Various non-digestible saccharides increase intracellular calcium ion concentration in rat small-intestinal enterocytes, Br J Nutr 92(5) (2004) 751-5.
[80] T. Suzuki, H. Hara, Various nondigestible saccharides open a paracellular calcium transport pathway with the induction of intracellular calcium signaling in human intestinal Caco-2 cells, J Nutr 134(8) (2004) 1935-41.
[81] K. Shiga, H. Hara, T. Suzuki, M. Nishimukai, A. Konishi, Y. Aoyama, Massive large bowel resection decreases bone strength and magnesium content but not calcium content of the femur in rats, Nutrition 17(5) (2001) 397-402.
[82] H. Tsuchita, T. Suzuki, T. Kuwata, The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats, Br J Nutr 85(1) (2001) 5-10.
[83] H. Hara, T. Suzuki, Y. Aoyama, Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats, Br J Nutr 84(5) (2000) 655-61.
[84] H. Hara, T. Suzuki, T. Kasai, Y. Aoyama, A. Ohta, Ingestion of guar gum hydrolysate, a soluble fiber, increases calcium absorption in totally gastrectomized rats, J Nutr 129(1) (1999) 39-45.
[85] H. Hara, T. Suzuki, T. Kasai, Y. Aoyama, A. Ohta, Ingestion of guar-gum hydrolysate partially restores calcium absorption in the large intestine lowered by suppression of gastric acid secretion in rats, Br J Nutr 81(4) (1999) 315-21.
[86] K. Saito, T. Hira, T. Suzuki, H. Hara, A. Yokota, F. Tomita, Effects of DFA IV in rats: calcium absorption and metabolism of DFA IV by intestinal microorganisms, Biosci Biotechnol Biochem 63(4) (1999) 655-61.
[87] T. Suzuki, H. Hara, T. Kasai, F. Tomita, Effects of difructose anhydride III on calcium absorption in small and large intestines of rats, Biosci Biotechnol Biochem 62(5) (1998) 837-41.